Puppy Nipping Mouth

What are the best methods to stop your puppy to bite?
I have 3 months Shih Tzu Poodle mix, she is always the most pretty and very sweet. But everyonce in a while 'as its goes into psycho mode and what does this mean bite. Its when she gets a piece of paper or toilet paper in his mouth and you go to pull out. She is vicious. Its hard to get my hands around his mouth shut and say no. Do not want to end up with a dog means so I want to nip in the bud this time. That What is your advice? Thanks so much.
say, he did not do it ... And he continues to say NO and then bitting Spang him and put him in a room by him-self ..........
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